A three-character code brings relief to patients with psoriasis and sheds light on complex immunoregulation processes: IL-4, an abbreviation for the endogenous signaling molecule Interleukin 4. The substance's ability to inhibit inflammation is well known, but its mechanism of action was not fully understood. Scientists have now shown in an animal model and in a study on patients how IL-4 helps against psoriasis at the molecular level.
Many patients suffering from psoriasis showed significant recovery after just a single dose of an experimental treatment with a human antibody that blocks an immune signaling protein crucial to the disease, researchers report. By the end of the trial nearly all of the 31 patients to receive treatment saw dramatic, if not complete, improvement in their symptoms.
The results of a large population study showed an increased risk of developing Psoriatic Arthritis among psoriasis patients exposed to physical trauma, particularly when the trauma involved bone and/or joints.
A phase II clinical trial shows that a new psoriasis drug called guselkumab has greater efficacy than the current standard of care for the chronic skin condition. Psoriasis is an immune-mediated disease that causes itchy, dry and red skin. It also increases a patient's risk for depression, heart disease and diabetes, among other conditions. The disease affects nearly 3 percent of the world's population.
An experimental, biologic treatment, brodalumab, achieved 100 percent reduction in psoriasis symptoms in twice as many patients as a second, commonly used treatment, according to the results of a multicenter clinical trial.
Psoriasis and psoriatic arthritis symptoms were significantly lessened in patients who underwent bariatric -- or weight loss -- surgery, according to researchers. According to the study's authors, the findings suggest that losing excess weight may improve symptoms in people who have these lifelong conditions.
In the first known study to examine the prevalence and treatment of psoriasis in older Americans, experts have found that black patients receiving Medicare are less likely to receive biologic therapies -medications derived from human or animal cells or tissues -- for the treatment of moderate to severe psoriasis than white patients.
Age plays a huge role when it comes to patients’ access to psoriasis treatment, research shows. Researchers who have examined if patients of varying ages have the same access to the most efficient psoriasis treatment, found that an age increase of 30 years resulted in an average 65 per cent reduction in likelihood of obtaining treatment with biologics.
Increasing the level of a naturally-produced protein, called tristetraprolin (TTP), significantly reduced or protected mice from inflammation, according to researchers. The results suggest that pharmaceutical compounds or other therapeutic methods that produce elevated levels of TTP in humans may offer an effective treatment for some inflammatory diseases, such as rheumatoid arthritis, psoriasis, and multiple sclerosis.
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease marked by painful abscesses that develop in areas where there are large numbers of sweat glands. The disease has been associated with cardiovascular risk factors, such as smoking and obesity, but the risk of cardiovascular disease in patients with HS is unknown.
While pregnant women with chronic skin conditions may fear that treating these conditions could compromise their baby’s health, a board-certified dermatologist can develop safe and effective treatment plans for these patients.
For the first time, researchers have linked psoriasis to the risk of widespread bone loss and describe how the protein IL-17 acts as a 'messenger' between the skin and the bones. IL-17 inhibitors, some of which already on the market, could simultaneously address skin inflammation and associated bone loss. These results recommend monitoring the bone mass of patients with psoriasis to select the most appropriate treatment. The study has potential implications in other autoimmune diseases such as inflammatory bowel disease.
Psoriasis is a long-lasting autoimmune disease that is characterized by patches of abnormal and inflamed skin. It is generally thought to have a genetic origin, which can be further triggered by environmental factors. People with specific mutations in the CARD14 gene have a high probability of developing psoriasis. A research team now reveals the molecular signaling mechanism by which mutations in CARD14 lead to increased inflammation in patients with psoriasis.
About half of Medicare patients who start taking biologic therapies for moderate to severe plaque psoriasis stop within a year, according to a new study. Previous studies have found similar results among the privately insured in the United States. The new study is the first to explore this issue among the elderly and disabled who are covered under Medicare. Lack of data in this population has been a major research gap, given that such patients are often underrepresented in clinical trials.
The chronic inflammatory skin disease psoriasis was associated with type 2 diabetes, body mass index and obesity in a study of Danish twins, and the study also suggests the possibility of a common genetic cause between psoriasis and obesity.
Despite regular washing and contact with bacteria-laden objects, our personal milieu of skin microbes remains highly stable over time, reports a metagenomics study. The authors say this knowledge could be applied to better understand a wide range of human skin disorders through the development of prebiotic, probiotic, and microbial transplantation approaches.