People receiving hormone therapy during gender transition had an elevated risk for cardiovascular events, such as strokes, blood clots and heart attacks. Findings underscore the importance of counseling and close monitoring of transgender patients receiving hormone therapy.
Researchers have identified a rare type of cancer cell that cannot make cholesterol, a key nutrient. By targeting this deficiency, scientists may be able to develop new strategies for treating the disease.
Setbacks in drug trials aiming to raise HDL have led researchers to reassess the particle's effects on heart health. A study combining proteomics and mouse genetics may help researchers understand researchers understand the proteins in the particle, how they get there and how they determine HDL function.
Excessive weight gain in children under two years can lead to cardiovascular and metabolic risk factors in teenage years including increased cholesterol, being overweight and having fat around the middle, finds new research.
Researchers have found that treating psoriasis, a chronic inflammatory skin disease, with biologic drugs that target immune system activity can reduce the early plaque buildup that clogs arteries, restricts blood flow, and leads to heart attacks and stroke. The findings highlight how immunotherapies that treat inflammatory conditions might play a role in the reduction of cardiovascular disease risks.
Statin therapy reduces major vascular events, and a new meta-analysis shows this is the case even in patients over 75 years of age. The research summarizes evidence from 28 randomized controlled trials, including 186,854 patients, 14,483 of whom were aged over 75.
Researchers have developed a novel microfluidic device for measuring in real-time the cholesterol secreted from liver tissue-chip containing human hepatocytes. This innovation can help researchers employing microfluidic cultures to study the effects of drugs such as statins on lowering cholesterol in real-time.
Observational studies and clinical trials conducted over nearly 40 years reveal the health benefits of eating at least 25g to 29g or more of dietary fiber a day, according to a series of systematic reviews and meta-analyses.
Researchers have demonstrated -- using fat cells derived from human stem cells -- that individual genetic variation can be used to predict whether the TZD rosiglitazone will produce the unwanted side effect of increasing cholesterol levels in certain individuals.