An 80-year-old from the Tsimane (pronounced chee-MAH-nay) group had the same vascular age as an American in his or her mid-fifties, suggests a new report. The Tsimane people -- a forager-horticulturalist population of the Bolivian Amazon -- have the lowest reported levels of vascular aging for any population, with coronary atherosclerosis (hardening of the arteries) being five times less common than in the US, the research shows.
Cholesterol-lowering drugs are important, especially on the day of coronary bypass surgery, remind researchers in a new report. Stopping statin medication even one day before CABG surgery may significantly affect patient outcomes, they say.
After a heart attack, it is important for patients to take medication that lowers cholesterol levels. In a new study, researchers found that general cognitive ability (intelligence) has a bearing, in the first year and two years after the heart attack, on how well men take statins prescribed for them.
A study demonstrates that the cholesterol present in cell membranes can interfere with the function of an important brain membrane protein, through a previously unknown mode of interaction. Specifically, cholesterol is capable of regulating the activity of the adenosine receptor, by invading it and accessing the active site. This will allow new ways of interacting with these proteins to be devised that in the future could lead to drugs for treating diseases like Alzheimer's.
Evolutionary biologists are weighing in based on the increasing power of DNA analyses to explore how changes in diet over eons have caused human adaptations to genes regulating fat metabolism. Researchers examined data from 101 Bronze Age individuals, and present-day human data from the 1000 Genomes Project. His team analyzed adaptive mutations in the FADS region in Europeans, to determine which mutations might have been targeted by recent natural selection in Europeans and to investigate the physiological effects of the mutations.
Statin drugs are widely used to manage high cholesterol and reduce the risk of cardiovascular disease. But in a new review of more than 50 studies, researchers cite reductions in liver inflammation and improvements in other related factors as reasons why statins make good candidates for treating chronic liver disease.
Building on their recent research focusing on a peptide designed to block the oxidant amplifying function of the cellular sodium-potassium pump, researchers have successfully demonstrated that pNaKtide, can attenuate the development of experimental nonalcoholic fatty liver disease (NAFLD) and atherosclerosis.
Women over 75 faced a 33 percent higher chance of developing diabetes if they were taking statins, new Australian research shows. The risk increased to 51 percent for those on high doses. Clinicians are urged to be aware of the risks when prescribing and carefully monitor elderly female patients.
Statin side effects are the strongest predictor of failure to meet low-density lipoprotein (LDL) cholesterol targets, according to new research. Other predictors were statin non-adherence and use of weaker statins.
Heart disease patients taking PCSK9 inhibitors to achieve very low levels of cholesterol do not experience an increase in adverse events, including memory impairment or nervous system disorders, but may have an increased risk of cataracts, according to a study.