Computational biologists have devised a software tool that can play a high-speed 'Match Game' to identify bioactive molecules and the microbial genes that produce them so they can be evaluated as possible antibiotics and other therapeutic agents.

Gorgeous scenery and craft brewing are two of the things New England does best. So why not combine them for the perfect New England day? From the mountains of New Hampshire to the shores of Maine, here are 7 #brewhikes to try. 1. North Western Massachusetts – North Adams Outdoorsy options are plentiful in this part of Western Mass. But if you’re up for a challenge, there’s no better hike than to the top of , the highest point in Massachusetts. Enjoy any one of the 70 trails within the reservation, like the challenging 9.6-mile loop to the peak that traces Henry David Thoreau’s 1844 hike, or a slightly more low-key 6.2-mile round-trip summit hike that takes about 4-5 hours from the Mount Greylock Campground. Once you’re at the top, take a moment to catch your breath and take in views that stretch to Vermont and New York. By this point you’ll be craving a cold one, and you’ll be in luck—because from the end of the trail it’s about a half-hour drive to . The space is a nod to North Adams’s industrial past, with gorgeous brick walls and a 40-foot bar made by local workers. Its diverse lineup of beers manages to bridge the divide between visiting art lovers (mind-bending contemporary art is right next door at Mass MoCA!) and the local crowd. Plus, there’s pizza. 2. South Western Massachusetts – Great Barrington If you find yourself in the southern stretch of the Berkshires, get a taste of the Appalachian Trail in , which has miles of hiking and multiuse trails. Walking on the Appalachian is generally an out-and-back that can be as long or as short as you like, but the forest’s most popular option is the gorgeous Benedict Pond Loop Trail, an easy hike that wraps 1.5 miles around a tree-fringed lake. After, swing by for their serious list of beers, plus a sprawling menu of sandwiches, salads, burgers, and more. Head straight through the dining room for the bar, where regulars’ mugs hang overhead and every possible surface is covered in coasters from breweries around the world. The tap list changes with the season, but the Black Bear Stout and Barrington Brown are local favorites. 3. Central Vermont – Woodstock & Vicinity Seven miles east of Woodstock, Quechee Gorge Trail is a pleasant 2.2-mile round-trip hike that starts at the visitors center and leads into Vermont’s deepest gorge, which was carved by retreating glaciers. On a hot day, it’s a lovely place to take a dip in the water. Follow up this short trail with a can from , which is about a half an hour drive away. Long Trail started filling kegs in 1989, and its flagship amber ale is now ubiquitous in Vermont. If that’s the only Long Trail brew you’ve tried, you’ll be astounded by the selection at the brewery, which keeps around 13 beers on tap. Standouts include the barrel-aged Triple Bag, but the bartenders are through-and-through beer geeks who can guide your selection. The brewery also has a menu of pub food featuring wings, burgers, and other beer-friendly meals. A raised walkway overlooks the bottling and brewing facility, giving you a fascinating bird’s-eye view of the action. 4. Northwest Vermont – Stowe Though it has a reputation for being a ski town, there’s plenty of hiking (and drinking!) options in Stowe. One of the best is the steep, 1.1-mile hike from Smuggler’s Notch Road to , a scenic body of water that dazzles in autumn. Once there, take the additional 1.4-mile loop around the pond, and then head back into town to treat yourself. Stowe is blessed with a wealth of locally-made craft beers, starting with the Austrian lagers at . Favorites include the malty Vienna Style Lager and the Helles Lager, and the Bierhall’s menu of Austrian pub food—think cheddar and beer soup, hot soft pretzels, and many kinds of sausages—are perfect pairings for the entire lineup. In contrast, the beers at are defined by their distinctiveness. The brewer is consistently creative, with seasonal specials along with a list of mainstays: Try the Pink ‘n’ Pale, an American pale ale brewed with a hint of bitter grapefruit. 5. Northwest Vermont – Burlington Just south of Burlington in Charlotte you’ll find , whose namesake low-lying peak offers incredible views of Lake Champlain, the Adirondacks, and more. Starting at the parking lot, the 1.9-mile Mount Philo Trail loops up to the summit. It’s a relatively easy, family-friendly hike with a huge payoff at the top. Back in Burlington, you’re not likely to run out of craft beer options—after all, Vermont has more breweries per capita than any other state! If all the choices make you think you’d like a tour guide (and chauffeur), you can hop on the bus with , which will take you to all the hotspots. has something for most beer lovers, starting with the flagship Conehead, a single hop wheat IPA that’s brewed with Citra hops and is aromatic and hoppy without being overpowering. Another favorite is the London Calling, an English ordinary bitter that’s malty and mellow—and not particularly bitter. makes European-style beers in a nondescript industrial building. The tasting room has more charm and is lined with old beer cans and historical images of Burlington. Try the hugely popular Yorkshire Porter, an English dark ale that’s rich and full bodied, or Argument, an English India pale ale that’s brewed true to style: strong and bitter. , a relatively recent addition to Burlington’s beer scene, has hoppy, aromatic beers made by passionate beer geeks. 6. Northwest New Hampshire – White Mountains & Franconia Range For the ultimate hike in the Franconia Range, plan for at least six hours on the , a rugged trail that goes up and over three peaks: Little Haystack Mountain, Mount Lincoln, and Mount Lafayette. You’ll climb 3,480 feet in about four miles, passing waterfalls, knife-edge ridges, and other scenic views. (Pro tip: for a slightly more moderate hike, try the instead.) Afterwards, it’s about a 15-minute drive north to the , which brews small-barrel batches of European-style beers that range from more familiar Hefeweizens to offbeat pours, like a sour brown wild ale, Leipzig-style gose, and Czech black lagers. If you’re feeling famished after the trek, take a seat in the historic riverside barn or kick back on the patio with one of their Neapolitan-style pizzas. 7. Southern Maine – Portland If urban “hikes” are more your thing, check out in Portland. Back Cove is a 3.6-mile paved trail that circles a small estuary just north of downtown. If you’re headed from north to south, the trail connects to the Eastern Promenade, a slender waterfront park that 2.1 miles end-to-end, with walking trails, a popular swimming beach, and jaw-dropping sunrise views. Check out for more maps and directions to some of the city’s best offerings. Afterwards, explore the cutting edge of American beer with a cluster of breweries that are walking distance from downtown. (The is also an option.) Don’t miss , which has a diverse list of beers on tap, including the flagship Daymark American Pale Ale, a gorgeously balanced brew made with locally grown rye. Devoted beer geeks should head next door to , which uses many local ingredients in its offerings, including whiskey, rum, gin, and the unusual Black Cap Barley Spirit, made entirely with Maine-grown barley and filtered through Maine maple charcoal. started in Kennebunkport, but the heart of Maine’s largest brewery is just on the edge of downtown Portland. The tasting room has a brewpub feel, with barrels of aging beers stacked high against the walls, and a huge selection of brews on draft. Finally, stop for a tasting at , which turns out beers beloved across New England, like the refreshing Allagash White and a rich-tasting tripel that packs a malty wallop.

Find more trails and ales to inspire your next #brewhike:

[hbg-title isbn="9781640491748" summary="Explore the best of New England’s historic cities, admire the famed fall foliage, and stroll the stunning coastline with Moon Travel Guides."/] Pin it for Later

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