The natural decline in lung function over a 10-year period was slower among former smokers with a diet high in tomatoes and fruits, especially apples, suggesting certain components in these foods might help restore lung damage caused by smoking.
Researchers revealed that abnormal delivery of zinc to lung cells contributes to obstructive pulmonary diseases. They further showed that mRNA splicing abnormalities are involved in the detailed mechanism. So far, the importance of zinc in the lung has only been understood from a nutritional aspect. This discovery is thought to be the first to clarify zinc's effects on the regulation of mRNA ligation (splicing), and its involvement in the onset of pulmonary diseases.
Researchers have discovered that genetic variations in the anatomy of the lungs could serve as indicators to help identify people who have low, but stable, lung function early in life, and those who are particularly at risk for chronic obstructive pulmonary disease (COPD) because of a smoke-induced decline in lung function.
Women who work as cleaners or regularly use cleaning sprays or other cleaning products at home appear to experience a greater decline in lung function over time than women who do not clean, according to new research.
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated they are essential to repairing lung tissue damaged by severe influenza and other respiratory ailments.
Three-quarters of chronic obstructive pulmonary disease (COPD) cases have their origins in poor lung function pathways beginning in childhood. These pathways are associated with exposures in childhood, and amplified by factors in adulthood, according to a cohort study. While smoking remains the biggest risk factor for COPD, the study demonstrates that childhood illnesses (such as asthma, bronchitis, pneumonia, allergic rhinitis, eczema) and exposures to parental smoking are also linked to the disease.
Chronic obstructive pulmonary disease (COPD) is widespread in China with 8.6 percent of the country's adult population -- almost 100 million people -- suffering from the chronic lung disease, according to a new study. The study, which provided lung-function screenings for more than 50,990 participants, is the largest survey of COPD across age groups ever conducted in China.
Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, but the mechanism remains unclear. Researchers studied the aging-like phenotype and its underlying mechanisms in a COPD mouse model. Double deletion of tetraspanins CD9 and CD81 in epithelial cells downregulated expression of the protein SIRT. As SIRT1 is a key molecule that protects against various lifestyle-related diseases and aging, these tetraspanins may serve as novel therapeutic targets for COPD and aging.
Chronic obstructive pulmonary disease, or COPD for short, is believed to be the third most common cause of death worldwide. However, because the underlying mechanism is still largely unknown, today's treatments can only slow progression of the disease. Scientists have now reported a previously unknown pathogenic mechanism, which they have already been able to prevent in the laboratory.
A study with more than 3,300 participants in 12 countries has established a relationship between occupational exposure to biological dusts, gases, fumes and pesticides and COPD. The researchers did a follow-up of the participants 20 years after the first assessment.
Researchers have developed a new computational way of analyzing X-ray images of lungs, which could herald a breakthrough in the diagnosis and assessment of chronic obstructive pulmonary disease (COPD) and other lung diseases.
Research suggests that an immune signalling protein called interleukin (IL)-26 is increased among chronic smokers with lung disease and this involvement reveals disease mechanisms of interest for developing more effective therapy for these hard-to-treat patients.
Inhaled vaporized cannabis does not appear to improve or worsen exercise performance and activity-related breathlessness in patients with advanced chronic obstructive pulmonary disease (COPD), according to a randomized controlled trial.