Researchers describe the benefits of in-home noninvasive ventilation therapy, which includes a type referred to as bilevel positive airway pressure, or BiPAP -- for many patients with chronic obstructive pulmonary disease (COPD). The team identified a number of benefits, including reduced mortality, fewer hospital admissions, lower risk of intubation, improved shortness of breath, and fewer emergency department visits.
Stiff collagen and stretchy elastin fibers packed together in rows allow the respiratory system to stretch and snap back into shape. Scientists previously thought these fibers govern the mechanics of the airways due to their composition. New research has instead observed that differences in the shape and form of tissue fibers influence respiratory elasticity. These findings will help scientists better understand lung diseases, from chronic diseases like COPD to the lung ailment associated with vaping.
People who carry around unhealthy amounts of weight don't just have heart disease and diabetes to worry about. Obesity is implicated in two thirds of the leading causes of death from non-communicable diseases worldwide and the risk of certain diseases differs for men and women.
In a proof-of-concept experiment, researchers say they have successfully used microscopic human-made particles to predict the severity of patients' chronic obstructive pulmonary disease (COPD) by measuring how quickly the particles move through mucus samples. The technique, say the researchers, could eventually help doctors deliver more effective treatments sooner.
Chronic obstructive pulmonary disease (COPD) is a progressive lung disease that's often associated with a variety of health problems, including chronic muscle pain and insomnia. Psychoactive drug classes, like cannabinoids, are often prescribed to help reduce pain, promote sleep and decrease breathlessness. A study has found that older adults with COPD were twice as likely to use prescription synthetic oral cannabinoids compared to older adults without COPD, raising safety concerns.
Scientists found that the lungs of vapers -- like the lungs of smokers -- have elevated levels of protease enzymes, a condition known to cause emphysema in smokers. The researchers also found that the nicotine in vaping liquids is responsible for the increase in protease enzymes.
Scientists investigating the effect of air pollution on lung health, in an animal model, have concluded that even low levels of exposure can have a detrimental effect on the lungs. They say the results have implications for government agencies responsible for urban planning.
A study of more than 300,000 people has found that exposure to outdoor air pollution is linked to decreased lung function and an increased risk of developing COPD. Lung function normally declines as we age, but the new research suggests that air pollution may contribute to the ageing process and adds to the evidence that breathing in polluted air harms the lungs.
New research shows that the asthma drug benralizumab failed to decrease annual COPD exacerbation rates for patients with moderate to very severe COPD, a history of frequent moderate and/or severe exacerbations, and eosinophilic inflammation.
Researchers revealed that the immune cells basophils caused emphysema in mice with COPD-like features induced by intranasal administration of elastase. They showed that basophils, previously linked mainly to allergies and fighting parasites, initiated a cascade of reactions eventually leading to the release of excess MMP-12 and the destruction of alveolar walls. The team hopes that the findings will lead to breakthroughs in the treatment of COPD.
Researchers have found a novel, pathogenic entity that is a fundamental link between chronic inflammation and tissue destruction in lungs of patients with COPD. These exosomes from activated neutrophils caused COPD damage when they were instilled into the lungs of healthy mice. Remarkably, neutrophil exosomes from the lung fluids of human patients with COPD and neonates with bronchopulmonary dysplasia also caused COPD lung damage when put into the lungs of healthy mice.