A team of scientists conducted a comprehensive analysis of worldwide COVID-19 data to identify key strategies moving forward to develop effective therapeutics. The scientists suggest that COVID-19 should be treated as an acute inflammatory disease and that severity of infection is associated with the dysregulation of inflammatory immune responses and subsequent inability to develop protective immunity from the virus.
An intriguing early symptom among some COVID-19 patients is the loss of the sense of smell and/or taste, which has led to the suspicion that the virus that causes the illness, SARS-CoV-2, could be targeting taste buds. But in a new report, initial data from mice suggest that might not be the case.
A new study concludes that opening clinics dedicated specifically to treating influenza can limit the number of people infected and help to 'flatten the curve,' or reduce the peak prevalence rate. While the work focused on influenza, the findings are relevant for policymakers seeking ways to reduce impacts of the ongoing COVID-19 pandemic.
Researchers have created a virus in the lab that infects cells and interacts with antibodies just like the COVID-19 virus, but lacks the ability to cause severe disease. This safer virus makes it possible for scientists who do not have access to high-level biosafety facilities to join the effort to find drugs or vaccines for COVID-19.
A vaccine additive known as an adjuvant can enhance responses to a vaccine containing the exotic avian flu virus H5N1, so that both rookie and veteran elements of the immune response are strengthened, according to a new study.
A new article investigating the differences in CT findings between coronavirus disease (COVID-19) pneumonia and influenza virus pneumonia found that most lesions from COVID-19 were located in the peripheral zone and close to the pleura, whereas influenza virus was more prone to show mucoid impaction and pleural effusion. The more important role of CT during the present pandemic is in finding lesions and evaluating the effects of treatment.
Current research indicates that unhealthy lifestyle choices, including smoking and lack of exercise, along with emotional stressors like social isolation and interpersonal conflicts are important risk factors for developing upper respiratory infections. It is possible these same factors also increase the risk of contracting COVID-19.
Infecting volunteers with COVID-19 may provide valuable insights for future rounds of vaccine testing, but would require very strict controls and is unlikely to advance the current slate of vaccines in advanced development, argues a group of infectious disease experts. Though model development would be laborious, it could ultimately be advantageous, allowing researchers to answer a broader range of questions about both the virus and vaccines designed to prevent it during later rounds of testing.
In the fight against COVID-19, researchers have developed a new, non-invasive strategy to identify areas at greatest risk for spreading the disease. The team is drawing on data from existing cellular wireless networks to pinpoint potential hotspots for increased viral transmission.
In order to better understand the spread of the novel coronavirus, new research examines trends in visits to outpatient clinics for influenza-like illnesses in March 2020 as compared to previous years.