Researchers have conducted a trial involving 144 patients to compare the effectiveness of a multidisciplinary clinic - involving gastroenterologists, dieticians, psychiatrists and physiotherapists - with usual gastroenterology specialist-only care.
Researchers have discovered a new class of pipeline drugs to relieve pain and reduce fever without the danger of addiction or damage to the liver or kidneys.
Researchers found the drugs were prescribed disproportionately to older adults, often concurrently with opioids, despite warnings against this dangerous combination.
In recent weeks, a multisystem hyperinflammatory condition has emerged in children in association with prior exposure or infection to SARS-CoV-2. A new case series examines the spectrum of imaging findings in children with the post-COVID-19 inflammatory condition known in the US as Multisystem Inflammatory Syndrome in Children (MIS-C).
Neuroscientists shed a new light on the mechanisms responsible for familial migraine: They show that a genetic dysfunction in specific brain cells of the cingulate cortex area strongly influences head pain occurrence.
Researchers have discovered that a single, 60-minute interaction with PARO actually improved mood as well as reduced mild or severe pain. When participants touched PARO, they experienced greater pain reduction than when it was simply present in their room.
Researchers have developed LIH383, a novel molecule that binds to and blocks a previously unknown opioid receptor in the brain, thereby modulating the levels of opioid peptides produced in the central nervous system (CNS) and potentiating their natural painkilling and antidepressant properties.
Researchers have identified two brain phenomena that may explain some of the side-effects of ketamine. Their measurements of the brain waves of sheep sedated by the drug may explain the out-of-body experience and state of complete oblivion it can cause.
Researchers found that the use of nitrous oxide (N2O) as a pain relief option for individuals in labor is safe for newborn children and laboring individual, and converting to a different form of pain relief such as an epidural or opioid is influenced by a woman's prior birth history and other factors.
Chronic pain can be reduced by stimulating the vagus nerve in the ear with electrodes. In a microanatomic study, the human ear has now been analyzed on a micrometer scale. A computer model was created, allowing scientists to find optimal spots and optimal pulse shapes for electric stimulation. The results have now been successfully tested on patients.
Depression, anxiety and PTSD might not be disorders at all, according to biological anthropologists. In the paper, the researchers propose a new approach to mental illness that would be informed by human evolution, noting that modern psychology, and in particular its use of drugs like antidepressants, has largely failed to reduce the prevalence of mental disorders.
Most pain research remains overwhelmingly based on the study of male rodents, continuing to test hypotheses derived from earlier experiments on males. This points to an important blind spot in pain research, particularly as it relates to advancing research into new pain medications.
Researchers examine the effectiveness of consuming hemp oil extracted from the whole cannabis plant using a chronic neuropathic pain animal model. Researchers showed that legal cannabis hemp oil reduced mechanical pain sensitivity 10-fold for several hours in mice with chronic post-operative neuropathic pain.
A research team has found a small area of the brain in mice that can profoundly control the animals' sense of pain. Somewhat unexpectedly, this brain center turns pain off, not on. It's located in an area where few people would have thought to look for an anti-pain center, the amygdala, which is often considered the home of negative emotions and responses, like the fight or flight response and general anxiety.
Scientists have uncovered a novel mechanism by which abnormalities in mitochondrial fission in endothelial cells contribute to inflammation and oxidative stress in the cardiovascular system. They further show how the fission-fusion balance can be stabilized to lower inflammation using salicylate, the main active ingredient in everyday pain-relieving drugs like aspirin.
Adding yoga to your regularly prescribed migraine treatment may be better than medication alone, according to a new study. The new research suggests yoga may help people with migraines have headaches that happen less often, don't last as long and are less painful.
Nerve cells have a special ion channel that has a key role in starting the electrical impulse that signals pain and is sent to the brain. New research finds that people who inherited the Neanderthal variant of this ion channel experience more pain.
