Scientists have developed a novel therapy to trick cancer cells into gobbling up what they think is their favorite food - cholesterol -- which actually triggers their destruction. What appears to them as a cholesterol-loaded particle is actually a synthetic nanoparticle that binds to the cancer cells and starves them to death. The study was in lymphoma cells but could be effective in ovarian and kidney cancer.
In a world first genetic study, researchers found that that long-term, heavy coffee consumption - six or more cups a day - can increase the amount of lipids (fats) in your blood to significantly heighten your risk of cardiovascular disease (CVD).
Scientists developed a highly efficient, targeted method for delivering gene editing machinery to specific tissues and organs, demonstrating the treatment of high cholesterol by targeting genes in the liver of mice, reducing cholesterol for over 3 months (and potentially more) with one treatment.
Most people relate cholesterol to heart health, but it is also a critical component in the growth and spread of brain cancer. Researchers recently discovered how cholesterol becomes dysregulated in brain cancer cells and showed that the gene responsible for it could be a target for future drugs.
Fish oil supplements are a billion-dollar industry built on a foundation of purported, but not proven, health benefits. Now, new research indicates that taking fish oil only provides health benefits if you have the right genetic makeup.
A researcher examined the role of cholesterol in both Alzheimer's disease and Type 2 diabetes to identify a small molecule that may help regulate cholesterol levels in the brain, making it a potential new therapeutic target for Alzheimer's disease.
Researchers have uncovered a long-sought link in the battle to control cholesterol and heart disease. The protein that interferes with low-density lipoprotein (LDL) receptors that clear 'bad' cholesterol from the blood was identified. Excess LDL cholesterol can lead to atherosclerosis -- a narrowing and hardening of arteries -- and ultimately, heart attack.
The ability of HDL particles (commonly known as 'good' cholesterol) to reduce inflammation in the cells that line blood vessels may help predict who is more likely to develop a heart attack or other serious heart-related event. Gauging the anti-inflammatory capacity of HDL cholesterol may one day improve standard heart disease risk assessment.
Atherosclerosis -- hardening of the arteries -- is now involved in the majority of deaths worldwide, and advances in our understanding of the biology of the disease are changing traditional views and opening up new avenues for treatment.
A team of researchers have identified a genetic mutation associated with exfoliation syndrome, characterized by abnormal protein material accumulating in the front of the eye. It is the most common cause of glaucoma, and a major cause of irreversible blindness. The findings could lead to further research on the causes of the systemic disorder and potential cures.
Vegetarians appear to have a healthier biomarker profile than meat-eaters, and this applies to adults of any age and weight, and is also unaffected by smoking and alcohol consumption, according to a new study in over 166,000 UK adults.
Having high blood pressure, high cholesterol and/or obesity from childhood through middle age were linked to poorer brain function by middle age. These cardiovascular risk factors were linked with low memory, learning, visual processing, attention span, and reaction and movement time. Strategies to prevent heart disease and stroke should begin in childhood to promote better brain health by middle age.
Chemotherapy can induce a painful peripheral neuropathy (CIPN), a chronic condition and common adverse effect for cancer patients undergoing treatment. Researchers have used a mouse model to demonstrate the pivotal role of cholesterol in CIPN, and proposed a novel therapeutic approach to reverse it.
Base editing is a novel gene editing approach that can precisely change individual building blocks in a DNA sequence. By installing such a point mutation in a specific gene, an international research team has succeeded in sustainably lowering high LDL cholesterol levels in the blood of mice and macaques. This opens up the possibility of curing patients with inherited metabolic liver diseases.
Nearly half a billion people have diabetes, but most aren't getting the kind of care that could make their lives healthier, longer and more productive, according to a new global study of data from people with the condition. Many don't even know they have the condition. Only 1 in 10 people with diabetes in the 55 low- and middle-income countries studied receive the type of comprehensive care that's been proven to reduce diabetes-related problems.