Scientists found a gene variant that affects cholesterol levels also could increase the risk of contracting typhoid fever. A common cholesterol-lowering drug could protect animal models against Salmonella Typhi, the culprit behind the potentially deadly infection. The findings give insight into the mechanisms that govern human susceptibility to infectious disease and point to possible avenues to protect against pathogens -- like Salmonella or Ebola -- whose entry into host cells is regulated by cholesterol.

Breast cancer cells with defects in the DNA damage repair-genes BRCA1 and BRCA2 have a mutational signature known in cancer genomics as 'Signature 3.' But not all breast tumor cells exhibiting Signature 3 have BRCA1 or BRCA2 mutations. Therefore, some consider Signature 3 a biomarker for 'BRCAness,' a sign of a breakdown in BRCA-related DNA repair in general and not BRCA damage in particular.

XBA Says: A surprisingly enjoyable city-sim-like game that fans of the genre will really enjoy.

Scientists found a gene variant that affects cholesterol levels also could increase the risk of contracting typhoid fever. A common cholesterol-lowering drug could protect animal models against Salmonella Typhi, the culprit behind the potentially deadly infection. The findings give insight into the mechanisms that govern human susceptibility to infectious disease and point to possible avenues to protect against pathogens -- like Salmonella or Ebola -- whose entry into host cells is regulated by cholesterol.

This chick got some good genes! Kaia Gerber stopped by Soho House in Malibu for a bite over the weekend, and the budding supermodel put her perfect physique on display in...

Staples offers Asus ROG Strix (GL553VDDS71) 15.6" Gaming Laptop, 7th Gen Core i7, 16GB RAM, 1TB HDD for $949.99. ...

WGTC writes: At first glance, F1 2017 may appear to be a minor update to an annual franchise, but the truth is that its a real evolution for the genre.

Harry Kalogirou at GameCloud writes: "Its hard to say whether or not Matterfall is another definitive win for Housemarque. Its a concept thats executed so well, and it perfectly encapsulates what makes this cathartic arcade genre so fun. At the same time, however, it fails to live up to titles like Resogun and Nex Machina that came before it due to a lack of additional game modes and addictive score attacking. Its platforming is well-designed, for the most part, boss fights are innovative, and, most importantly, its just damn fun to play casually. Its a beautifully vibrant and colourful side-scroller with a killer soundtrack that has a truly delightful first playthrough as you explore its varied environments. However, if you play Housemarque titles for their longevity, I cant fully recommend Matterfall unless youre willing to stick with its sometimes arduous nature and lack of content."

Elon Musk delivered a serious warning to the United Nations that essentially goes like this .... BEWARE THE KILLER ROBOTS!!! The genius behind Tesla, SpaceX and don't forget PayPal signed an open letter to the U.N. Convention on Certain Conventional...

Staples offers ASUS G11CDDS52 Gaming Desktop with 7th Gen Intel i5, 8GB memory, 1TB HDD, 6GB NVIDIA GeForce GTX 1060 for $859.99. ...