The compound folic acid-conjugated methyl-BETA-cyclodextrin (FA-M-BETA-CyD) has significant antitumor effects on folate receptor-ALPHA-expressing (FR-ALPHA (+)) cancer cells, researchers have found. The compound significantly reduced ATP production while simultaneously increased the production of reactive oxygen species. Side effects in animal models were minimal but further testing is still required to determine its safety.
Taking 2-minute brisk walks every 30 minutes and a half-hour walk each day reduces blood lipid levels when measured in response to a meal consumed around 24 hours after starting the activity, research shows for the first time.
Greater muscle strength is associated with better cognitive function in ageing men and women, according to a new study. The association of extensively measured upper and lower body muscle strength with cognitive function was observed, but handgrip strength was not associated with cognitive function.
A technique for inserting a gene into specific cell types in the adult brain can be used to alter the function of brain circuits and change behaviors in an animal model. The method will allow scientists to better understand what roles certain cell types play in the brain's complex circuitry. Researchers hope the approach might someday lead to developing treatments for conditions like epilepsy that might be curable by activating a small group of cells.
Even in advanced medical settings, sepsis is still very dangerous and accounts for over 400,000 deaths annually in the US alone. While new drugs are in development, a group of researchers has determined that a combination of intravenous vitamin C, corticosteroids (a steroid), and thiamine (vitamin B) may be effective in preventing progressive organ dysfunction and reducing the number of deaths from severe sepsis and septic shock.
A quick glance at any social media platform will tell you that people love taking photos of their experiences -- whether they're lying on the beach, touring a museum, or just waiting in line at the grocery store. New research shows that choosing to take photos may actually help us remember the visual details of our encounters.
And to think it was all right there in her garage. A load of boxes pulled from a biologist's home yielded a veritable treasure trove for researchers studying the impact of climate change on coastal biodiversity in California.
Scientists show how some pathogenic bacteria -- such as the mycobacteria that cause tuberculosis -- use a previously unknown mechanism to coordinate their division. The discovery could help develop new ways to fight them.
Researchers have discovered a new, yet simple, way to increase drought tolerance in a wide range of plants. The study reports a newly discovered biological pathway that is activated in times of drought. By working out the details of this pathway, scientists were able to induce greater tolerance for drought-like conditions simply by growing plants in vinegar.
Biodiversity losses from deep-sea mining are unavoidable and possibly irrevocable, an international team of scientists, economists and lawyers argue. They say the International Seabed Authority, which is responsible for regulating undersea mining in areas outside national jurisdictions, must recognize the risk and communicate it clearly to member states and the public to spur discussions as to whether deep-seabed mining should proceed, and if so, what safeguards are needed to minimize biodiversity loss.
The peanut and its kin -- legumes -- have not one, but two ways to make the amino acid tyrosine. That might seem small, but why this plant family has a unique way to make such an important chemical building block is a mystery that extends back to the 1960s.
Discovering the function of a gene requires cloning a DNA sequence and expressing it. Until now, this was performed on a one-gene-at-a-time basis, causing a bottleneck. Scientists have invented a technology to clone thousands of genes simultaneously and create massive libraries of proteins from DNA samples, potentially ushering in a new era of functional genomics.
A new microscope could provide accurate real-time results during cancer-removal surgeries, potentially eliminating the 20 to 40 percent of women who have to undergo multiple lumpectomy surgeries because cancerous breast tissue is missed the first time around.
Researchers created an atomically thin material and used X-rays to measure its exotic and durable properties that make it a promising candidate for a budding branch of electronics known as 'spintronics.'
Mounting scientific evidence shows that exercise is good not only for our bodies, but for our brains. Yet, exactly why physical activity benefits the brain is not well understood. Researchers suggest that the link between exercise and the brain is a product of our evolutionary history and our past as hunter-gatherers.
A team of archaeologists from Belgium, the United States and Egypt has uncovered some previously unknown rock inscriptions, which include 5,200-year-old Egyptian hieroglyphs, at the archaeological site of El-Khawy, near the ancient Egyptian city of Elkab. “This newly discovered rock art site preserves some of the earliest - and largest - signs from the formative [...]
Global solar energy production is taking a major hit due to air pollution and dust. The first study of its kind shows airborne particles and their accumulation on solar cells is cutting energy output by more than 25 percent in certain parts of the world. The regions hardest hit are also those investing the most in solar energy installations -- China, India and the Arabian Peninsula.
Engineers have developed a new way to dive into the cell's tiniest and most important components. What they found inside membraneless organelles surprised them, and could lead to better understanding of fatal diseases including cancer, Huntington's and ALS.
Billions of pieces of plastic are floating in the oceans. Their effects are also sufficiently well-known: marine animals swallow them or get tangled up in them, which can cause them to die in agony. On the other hand, we know less about the consequences of the smallest pieces of plastic, known as microplastics. Researchers have now started to investigate how microplastics are generated and where they actually come from.