As scientists increasingly rely on eyewitness accounts of earthquake shaking reported through online systems, they should consider whether those accounts are societally and spatially representative for an event, according to a new article.
Researchers have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study.
Researchers have discovered a new enzymatic function of the Epstein-Barr Virus (EBV) protein EBNA1, a critical factor in EBV's ability to transform human cells and cause cancer. Study provides new indications for inhibiting EBNA1 function, opening up fresh avenues for development of therapies to treat EBV-associated cancers.
In nature, many things have evolved that differ in size, color and, above all, in shape. While the color or size of an object can be easily described, the description of a shape is more complicated. Researchers have now outlined a new and improved way to describe shapes based on a network representation that can also be used to reassemble and compare shapes.
Electrical trigger sites in neurons surprisingly change with experience; they are either becoming smaller with increasing number of experiences and, vice versa, they grow larger when less input arrives in the brain.
Scientists have built hair-thin optical fiber filters in a very simple way. They are not only extremely compact and stable, but also color-tunable. This means they can be used in quantum technology and as sensors for temperature or for detecting atmospheric gases.
Robots are widely used to build cars, paint airplanes and sew clothing in factories, but the assembly of microscopic components, such as those for biomedical applications, has not yet been automated. Lasers could be the solution. Now, researchers have used lasers to create miniature robots from bubbles that lift, drop and manipulate small pieces into interconnected structures.
A new study shows that humans express a powerful hormone during exercise and that treating mice with the hormone improves physical performance, capacity and fitness. Researchers say the findings present new possibilities for addressing age-related physical decline.
Various software packages can be used to evaluate products and predict failure; however, these packages are extremely computationally intensive and take a significant amount of time to produce a solution. Quicker solutions mean less accurate results.
A new study collected and analyzed the largest single dataset of neurons' electrical activity to glean principles of how we perceive the visual world around us. The study captures the hundreds of split-second electrical signals that fire when an animal is interpreting what it sees.
Researchers have developed a predictive theory for tumor growth that approaches the subject from a new point of view. Rather than focusing on the biological mechanisms of cellular growth, the researchers instead use thermodynamics and the physical space the tumor is expanding into to predict its evolution from a single cell to a complex cancerous mass.
Polymer and radionuclide chemists report major advance in microcapsule drug delivery systems. Their microcapsules -- labeled with radioactive zirconium-89 -- are the first example of hollow polymer capsules capable of long-term, multiday positron emission tomography imaging in vivo. In previous work, the researchers showed that the hollow capsules could be filled with a potent dose of the cancer drug doxorubicin, which could then be released by therapeutic ultrasound that ruptures the microcapsules.
In the dark waters of Lake Superior, a fish species adapted to regain a genetic trait that may have helped its ancient ancestors see in the ocean, a study finds. 'Evolution is often thought of as a one-way process, at least over deep time, but in this example, over 175 million years, we have this reversal back to a much earlier ancestral state,' one of the researchers says.
For the study 40 infants of women diagnosed with postpartum depression were matched with 40 infants of non-depressed mothers on infant age, gender and socioeconomic status. The mothers with postpartum depression received nine weeks of group CBT. The infants were all tested before the treatment and nine weeks later, including a questionnaire on the infant behaviour completed by the mother and her partner.
A new article reports two patients appear to have been cured of beta thalassemia and sickle cell disease after their own genes were edited with CRISPR-Cas9 technology. The two researchers who invented this technology received the Nobel Prize in Chemistry in 2020.
Researchers describe the effects of antibiotics on membrane vesicles, demonstrating that such drugs actively modify the properties of vesicle transport. Under the influence of antibiotics, MVs were produced and released by bacteria in greater abundance and traveled faster and further from their origin. The work sheds new light on these important information-carrying entities, implicated in many cellular communication processes, including antibiotic resistance.
If ‘stupendously large’ black holes, those with masses more than 100 billion times that of the Sun, exist in the Universe, they would provide a powerful tool for cosmological tests due to their unique imprints, according to a paper published in the Monthly Notices of the Royal Astronomical Society. “Black holes are a key prediction [...]