New research reveals that a novel drug reverses memory deficits and stops Alzheimer disease pathology (AD) in an animal model. Importantly, this drug has already proven to be non-toxic for humans in a clinical setting and could, therefore, be brought quickly to trials in humans against AD.
The study used rats to examine the impact on emotional behavior of a sudden drop in blood sugar. When the rats were given a glucose blocker, researchers found they had higher levels of cortisol. They also showed signs of stress and sluggish behavior similar to a poor mood. To prove the behavior wasn't just a lack of glucose to the muscles, researchers then gave them a common antidepressant and the behavior disappeared.
Neurologists have provided, for the first time, evidence that blood deposits in the brain may not require a blood vessel tear. The researchers found that brain endothelial cells, the cells that line blood vessels of the brain, have the capacity for engulfing red blood cells and depositing them outside the blood vessels and into the substance of the brain, without requiring a disruption of the vasculature.
Scientists have identified acquisition of two types of internal models for motor control, which are likely to be stored in the cerebellum. They show that motor control in human hand reaching movement relies on two types of motor learning: (i) acquisition of explicit motor control and (ii) acquisition of implicit motor control.
For individuals carrying a genetic mutation that causes Alzheimer's disease, engaging in at least 2.5 hours of physical activity per week may have beneficial effects on markers of Alzheimer's disease brain changes and may delay cognitive decline, according to a new study.
Science projects within controversial fields such as synthetic biology could benefit from experimenting with communication settings in which experts share their thoughts and feelings with each other and the public. This allows for a more open and constructive dialogue with the public about research - and may even generate new research ideas, new research suggests.
Researchers have discovered a way to halt the invasion of the toxoplasmosis-causing parasite into cells, depriving the parasite of a key factor necessary for its growth. The findings are a key step in getting closer to a vaccine to protect pregnant women from the parasite Toxoplasma gondii, which carries a serious risk of miscarriage or birth defects.
Some patterns of electrical activity generated by the brain during sleep are inherited, according to a study of teenage twins. Pinpointing the relative contributions of biology and experience to sleep neurophysiology could inform therapies for numerous psychiatric disorders in which alterations in brain activity during sleep can be detected.
Is there a link between differences in IQ test performance and the activity of certain genes? Researchers have shown that modifications in the structure of a specific gene have a negative impact on individual test performance. This suggests that environmentally-induced epigenetic changes to our genetic material have a greater impact on intelligence than previously thought.