New research shows that the asthma drug benralizumab failed to decrease annual COPD exacerbation rates for patients with moderate to very severe COPD, a history of frequent moderate and/or severe exacerbations, and eosinophilic inflammation.
Researchers revealed that the immune cells basophils caused emphysema in mice with COPD-like features induced by intranasal administration of elastase. They showed that basophils, previously linked mainly to allergies and fighting parasites, initiated a cascade of reactions eventually leading to the release of excess MMP-12 and the destruction of alveolar walls. The team hopes that the findings will lead to breakthroughs in the treatment of COPD.
Researchers have found a novel, pathogenic entity that is a fundamental link between chronic inflammation and tissue destruction in lungs of patients with COPD. These exosomes from activated neutrophils caused COPD damage when they were instilled into the lungs of healthy mice. Remarkably, neutrophil exosomes from the lung fluids of human patients with COPD and neonates with bronchopulmonary dysplasia also caused COPD lung damage when put into the lungs of healthy mice.
For people with conditions such as cystic fibrosis and COPD, mucus can get too thick and sticky; coughing alone can't clear it. Infections develop, leading to severe chronic disease and early death. Now, for the first time, scientists have shown why coughing often cannot tear mucus apart and away from the airway lining. And they showed how to make mucus thinner and less sticky so coughing can become a therapeutic aid.
As a cold ends, a severe mucus cough starts. Sound familiar? Two studies now give explanations: First, crucial mechanisms of the mucus in both diseased and healthy airways; second, what happens in such chronic lung diseases as cystic fibrosis and chronic obstructive pulmonary disease (COPD).
Long-term use of benzodiazepine medications in patients with chronic obstructive pulmonary disease, or COPD, as well as posttraumatic stress disorder (PTSD) may lead to increased suicide risk, according to a new study.
First results from a clinical trial of a procedure to open obstructed airways in patients with chronic obstructive pulmonary disease (COPD) have shown that it significantly reduces problems associated with the disease and is safe.
Abnormal levels of more than two dozen metabolites -- chemicals produced in the body as it breaks down fats, proteins and carbohydrates -- can reliably predict which Sept. 11 firefighters developed lung disease and which did not, a new analysis shows.
E-cigarette vapor boosts the production of inflammatory chemicals and disables key protective cells in the lung that keep the air spaces clear of potentially harmful particles, reveals a small experimental study.