A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.
Transcription factors, the tiny proteins that switch genes on or off in the nucleus of cells, are considered unreachable molecular targets for drugs attempting to treat medical conditions. Overcoming this challenge, researchers discovered a small molecular compound that successfully blocks a transcription factor and its pro-inflammatory and hyper-mucous activity in asthma. In a study, scientists tested a new compound they call RCM-1.
The prevalence of past-year generalized anxiety disorder (GAD) for adults aged 50 and older with chronic obstructive pulmonary disease (COPD) is much higher compared to older adults without COPD (5.8 percent vs 1.7 percent), according to a new study.
The key to an inherited deficiency, predisposing people to emphysema and other lung conditions, could lie in their Viking roots. Archaeological excavations of Viking latrine pits in Denmark have revealed that these populations suffered massive worm infestations. The way that their genes developed to protect their vital organs from disease caused by worms has become the inherited trait which can now lead to lung disease in smokers.
Patients with COPD demonstrated gray matter decreases in areas of the brain that process breathlessness, fear and sensitivity to pain. The study found patients with COPD show regionally decreased gray matter volume in the anterior, mid, and posterior cingulate cortex, hippocampus, and amygdala. Levels of degeneration in certain areas of the brain were also impacted by longer disease duration. Those individuals showed a greater fear of breathlessness and fear of physical activity, which can affect the course of the disease.
The classic stethoscope has entered the digital age. Medical researchers have created a computer program that connects to an electronic stethoscope to classify lung sounds into five common diagnostic categories, with a high sensitivity for lung sounds, advancing diagnosis accuracy.
Researchers investigated differences in care given to chronic obstructive pulmonary disease patients by medical doctors compared with nurse practitioners and physician assistants, and report their findings in a new article.
Researchers identify new process for preventing narrowing of airways that could lead to new treatments for disease. Millions of people suffer with asthma, with the disease affecting one in every 11 people and one in five households.
A new study backs up observations in chronic obstructive pulmonary disease patients showing reduced effectiveness of symptom-reliever medication in flare-ups linked to cigarette smoking and infection with viruses such as influenza.
Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung illness and the third leading cause of death in the United States. Scientists have long believed that inhaling toxic gases and particles from tobacco smoke causes inflammation of the small airways in the lungs, leading to the development of COPD. However, the theory doesn't explain why airway inflammation and disease progression continue even after the patient stops smoking. A new study shows that persistent inflammation in COPD may result from a defect in the immune system that allows airway bacteria to invade deeper into the lung.
Debilitating symptoms from chronic obstructive pulmonary disease (COPD) can worsen in patients who also experience depression, research suggests. Patients who had pre-existing depression or developed depression after COPD diagnosis were more likely to experience heightened COPD symptoms, such as increased breathlessness, reduced exercise tolerance and hopelessness.
In the largest and longest US analysis of persistent asthmatics to date, investigators have found a link between persistent childhood asthma and chronic obstructive pulmonary disease in early adulthood. The study found that early lung function predicts lung growth later in life, regardless of asthma treatment and smoking exposure.