Researchers describe how the concentration of mucins -- the proteins that make mucus thick -- is abnormally high in chronic bronchitis and that high mucin concentrations are associated with disease severity in people with chronic bronchitis. This finding could become the first-ever objective marker of chronic bronchitis and lead to the creation of diagnostic and prognostic tools.
In a new study, CT-measured vascular pruning – the diminution of distal pulmonary blood vessels (vessels on the outer edges of the lungs) – was associated with increased risk of death in smokers without chronic obstructive pulmonary disease (COPD).
Cystic fibrosis (CF) alters the structure of mucus produced in airway passages. In pigs affected by CF, mucus strands (made of MUC5B protein) are more tangled than normal, and the sheets of mucus (made of MUC5AC protein) that cover the strands are denser. These structural abnormalities may help explain why people with CF have difficulty clearing mucus from their lungs.
Older adults with COPD who recently started using opioids have an increased risk of coronary artery disease-related death compared to non-opioid users, researchers have found. Among these patients, new opioid use is associated with a 215 percent increase in coronary artery disease-related death for long-term care residents and an 83 percent increase in coronary artery disease-related death for those who lived at home compared to non-opioid users, according to the study.
Scientists have examined the current information available from many different sources on diagnosing and managing mild to moderate asthma in adults and summarized them. They determined that essential, effective treatment must involve a physical and breathing exam, a comprehensive health history of the patient and ask questions that may answer what triggers may cause an asthma attack.
A team of scientists has developed promising research towards a possible stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis -- often-fatal conditions that affect tens of millions of Americans.
Latest global estimates illustrate the vast impact of the two most common chronic respiratory diseases, with 3.2 million deaths from chronic obstructive pulmonary disease (COPD) and 0.4 million deaths caused by asthma in 2015, according to a new Global Burden of Disease study. COPD is a group of lung conditions (including emphysema and chronic bronchitis) that cause breathing difficulties.