A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis. Although, still at a pre-clinical stage, these findings have important potential implications for the future treatment of patients.
Transcription factors, the tiny proteins that switch genes on or off in the nucleus of cells, are considered unreachable molecular targets for drugs attempting to treat medical conditions. Overcoming this challenge, researchers discovered a small molecular compound that successfully blocks a transcription factor and its pro-inflammatory and hyper-mucous activity in asthma. In a study, scientists tested a new compound they call RCM-1.
Scientists have created a graphene-based sensor that could lead to earlier detection of looming asthma attacks and improve the management of asthma and other respiratory diseases, preventing hospitalizations and deaths.
Patients suffering from severe lung disease could see their lives transformed thanks to a 'game-changing' clinical trial. The HOT-HMV trial (Home Oxygen Therapy-Home Mechanical Ventilation), which involved giving selected patients a breathing machine to be used in their home in addition to oxygen therapy, was found to reduce readmissions to hospital following an acute infection.
In a new study, CT-measured vascular pruning – the diminution of distal pulmonary blood vessels (vessels on the outer edges of the lungs) – was associated with increased risk of death in smokers without chronic obstructive pulmonary disease (COPD).
Cystic fibrosis (CF) alters the structure of mucus produced in airway passages. In pigs affected by CF, mucus strands (made of MUC5B protein) are more tangled than normal, and the sheets of mucus (made of MUC5AC protein) that cover the strands are denser. These structural abnormalities may help explain why people with CF have difficulty clearing mucus from their lungs.
Older adults with COPD who recently started using opioids have an increased risk of coronary artery disease-related death compared to non-opioid users, researchers have found. Among these patients, new opioid use is associated with a 215 percent increase in coronary artery disease-related death for long-term care residents and an 83 percent increase in coronary artery disease-related death for those who lived at home compared to non-opioid users, according to the study.
Scientists have examined the current information available from many different sources on diagnosing and managing mild to moderate asthma in adults and summarized them. They determined that essential, effective treatment must involve a physical and breathing exam, a comprehensive health history of the patient and ask questions that may answer what triggers may cause an asthma attack.
A team of scientists has developed promising research towards a possible stem cell treatment for several lung conditions, such as idiopathic pulmonary fibrosis (IPF), chronic obstructive pulmonary disease (COPD), and cystic fibrosis -- often-fatal conditions that affect tens of millions of Americans.
Latest global estimates illustrate the vast impact of the two most common chronic respiratory diseases, with 3.2 million deaths from chronic obstructive pulmonary disease (COPD) and 0.4 million deaths caused by asthma in 2015, according to a new Global Burden of Disease study. COPD is a group of lung conditions (including emphysema and chronic bronchitis) that cause breathing difficulties.
Researchers describe how the concentration of mucins -- the proteins that make mucus thick -- is abnormally high in chronic bronchitis and that high mucin concentrations are associated with disease severity in people with chronic bronchitis. This finding could become the first-ever objective marker of chronic bronchitis and lead to the creation of diagnostic and prognostic tools.