First results from a clinical trial of a procedure to open obstructed airways in patients with chronic obstructive pulmonary disease (COPD) have shown that it significantly reduces problems associated with the disease and is safe.
Abnormal levels of more than two dozen metabolites -- chemicals produced in the body as it breaks down fats, proteins and carbohydrates -- can reliably predict which Sept. 11 firefighters developed lung disease and which did not, a new analysis shows.
E-cigarette vapor boosts the production of inflammatory chemicals and disables key protective cells in the lung that keep the air spaces clear of potentially harmful particles, reveals a small experimental study.
Inhaled vaporized cannabis does not appear to improve or worsen exercise performance and activity-related breathlessness in patients with advanced chronic obstructive pulmonary disease (COPD), according to a randomized controlled trial.
Research suggests that an immune signalling protein called interleukin (IL)-26 is increased among chronic smokers with lung disease and this involvement reveals disease mechanisms of interest for developing more effective therapy for these hard-to-treat patients.
Researchers have developed a new computational way of analyzing X-ray images of lungs, which could herald a breakthrough in the diagnosis and assessment of chronic obstructive pulmonary disease (COPD) and other lung diseases.
A study with more than 3,300 participants in 12 countries has established a relationship between occupational exposure to biological dusts, gases, fumes and pesticides and COPD. The researchers did a follow-up of the participants 20 years after the first assessment.
Chronic obstructive pulmonary disease, or COPD for short, is believed to be the third most common cause of death worldwide. However, because the underlying mechanism is still largely unknown, today's treatments can only slow progression of the disease. Scientists have now reported a previously unknown pathogenic mechanism, which they have already been able to prevent in the laboratory.
Chronic obstructive pulmonary disease (COPD) is a disease of accelerated lung aging, but the mechanism remains unclear. Researchers studied the aging-like phenotype and its underlying mechanisms in a COPD mouse model. Double deletion of tetraspanins CD9 and CD81 in epithelial cells downregulated expression of the protein SIRT. As SIRT1 is a key molecule that protects against various lifestyle-related diseases and aging, these tetraspanins may serve as novel therapeutic targets for COPD and aging.
Chronic obstructive pulmonary disease (COPD) is widespread in China with 8.6 percent of the country's adult population -- almost 100 million people -- suffering from the chronic lung disease, according to a new study. The study, which provided lung-function screenings for more than 50,990 participants, is the largest survey of COPD across age groups ever conducted in China.
Three-quarters of chronic obstructive pulmonary disease (COPD) cases have their origins in poor lung function pathways beginning in childhood. These pathways are associated with exposures in childhood, and amplified by factors in adulthood, according to a cohort study. While smoking remains the biggest risk factor for COPD, the study demonstrates that childhood illnesses (such as asthma, bronchitis, pneumonia, allergic rhinitis, eczema) and exposures to parental smoking are also linked to the disease.
Researchers have identified a lung stem cell that repairs the organ's gas exchange compartment. They isolated and characterized these progenitor cells from mouse and human lungs and demonstrated they are essential to repairing lung tissue damaged by severe influenza and other respiratory ailments.